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Course Detail

BS3344 Undergrad Advanced Experimental Biology (UAEB) Workshop (Series II) – Macromolecular Crystallography
The aim of this one-week intensive course is to provide a hands-on approach to practical modern biological macromolecular crystallography. Upon successfully completing this course, learner should be able to:

Summarise and explain a research paper describing macromolecular structures determined by X-ray crystallography.
Set-up crystallization experiments
Collect diffraction data on a home source and process these data using standard software.
Determine medium difficulty macromolecular structure using CCP4 software.
a) How to grow crystals?
b) How to analyze, optimize, and soak crystals?
c) How to harvest and freeze crystals?
d) How to collect diffraction data?e) How to process diffraction data using CCP4?
e) How to solve crystal structures by molecular replacement using CCP4?
f) How to phase using MIR, SIR, SIRAS, SAD/MAD – sulfur, selenium, halides, metals using CCP4?
g) How to build and refine a 3D model of a macromolecule using CCP4?
h) How to evaluate the accuracy/correctness of a 3D macromolecular model using CCP4?
i) How to interpret the model in connection with other results (SAXS, EM, biochemistry)?
Who Should Attend
Diploma/Degree in Biological Sciences and equivalent with 2 years of related working experience.
Eligibility Criteria
Reasearchers working in academia and the local biotech industry

Date(s): 09 Aug 2021 to 03 Dec 2021
Time: Refer to Class and Exam Schedules
Venue: NTU
Closing Date of Registration: 15 Nov 2020
Course Fee Payable:(Inclusive of GST) Refer to the course fee table

E2I No
Academic Units (AU)
Number of AU: 3
Online Registration
Method of Payment
  1. Online Credit/Debit Card Payment (VISA and Mastercard only)
  2. Cash/Cheque/NETS payment at One-Stop@SAC (NTU Main Campus)
Withdrawal & Refund Policy

Once payment is made, applicant is committed to the completion of course. Course fee refunds will not be considered.

Terms and Conditions
  1. Course is subject to a minimum participation number before commencement.
  2. Course is subject to a first-come-first-serve basis.
  3. Registration is non-transferable.
  4. Student must meet all eligibility criteria for admission.
  5. Student is required to complete all assessments for each course.
  6. PaCE@NTU​ reserves the right to change or cancel any course or lecturer due to unforeseen circumstances.
  7. All details are correct at time of dissemination.
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