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Course Detail

BS4018 Biology of Aging and Neurodegeneration
The aim of this course is to understand pathologic mechanisms underlying neurodegenerative diseases at the molecular and cellular level. The hallmark of those aging-associated diseases, like Alzheimer's and Parkinson's, is protein aggregation that occurs when protein homeostasis collapses. Cellular protein homeostasis is maintained by regulating protein synthesis, folding and degradation. Therefore, this course will address the whole life cycle of proteins and you will learn how failure of each step of the cycle is linked with neurodegenerative diseases. Various genes and pathways involved in aging are also an important topic of the course. This course will help you understand why debilitating neurodegenerative diseases are on the increase in our society and how to approach to cure them.
a) Molecular pathology of neurodegenerative diseases (Alzheimer, Parkinson, ALS, Prion etc.)
b) Function and mechanism of autophagy
c) Cellular pathways associated with aging (e.g. mTOR pathway)
d) Cellular mechanisms to sequester protein aggregates
e) Function and mechanism of chaperone families
f) Mechanism of the protein degradation machinery, proteasome
g) Mechanism of the protein synthesis machinery, ribosome
h) Mechanism to select ubiquitination targets
i) Cellular responses to protein folding/synthesis stresses
Who Should Attend
Reasearchers working in academia and the local biotech industry.
Eligibility Criteria
Diploma/Degree in Biological Sciences and equivalent with 2 years of related working experience.
Date(s): 11 Jan 2021 to 07 May 2021
Time: Refer to Class and Exam Schedules
Venue: SBS-CR1
Closing Date of Registration: 30 Nov 2020
Course Fee Payable:(Inclusive of GST) Refer to the course fee table

E2I No
Academic Units (AU)
Number of AU: 3
Online Registration
Method of Payment
  1. Online Credit/Debit Card Payment (VISA and Mastercard only)
  2. Cash/Cheque/NETS payment at One-Stop@SAC (NTU Main Campus)
Withdrawal & Refund Policy

Once payment is made, applicant is committed to the completion of course. Course fee refunds will not be considered.

Terms and Conditions
  1. Course is subject to a minimum participation number before commencement.
  2. Course is subject to a first-come-first-serve basis.
  3. Registration is non-transferable.
  4. Student must meet all eligibility criteria for admission.
  5. Student is required to complete all assessments for each course.
  6. PaCE@NTU​ reserves the right to change or cancel any course or lecturer due to unforeseen circumstances.
  7. All details are correct at time of dissemination.
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